N,N'-Dimethylthiourea 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (?OH) 的清除剂，通过活化的中性粒细胞在体外阻止 ?OH 的产生。N,N'-Dimethylthiourea 通过发挥 ?OH 清除和抗炎作用，防止水浸限制应激诱导的大鼠胃粘膜损伤。

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] .

N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1]. DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response.

534-13-4

C3H8N2S

104.17

DMTU;N,N-二甲基硫脲

DMSO:250 mg/mL (2399.92 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years