SAR-405 是一种选择性 PIK3C3/Vps34 抑制剂，IC50为1.2 nM，Kd为1.5 nM，可防止自噬并与肿瘤细胞中的 mTOR 抑制协同作用。它抑制饥饿或 mTOR 抑制诱导的自噬，具有抗癌活性。

SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.

SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases.?Inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes.?SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition.?SAR405 prevents autophagosome formation (IC50: 42 nM).?Treatment of starved cells with SAR405 fully inhibits the conversion to LC3-II in a dose-dependent manner.?The GFP-LC3 model is used for the HTS and confirmed its activity on starved cells (IC50=419 nM) [1][2].

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C19H21ClF3N5O2

443.85

DMSO:27 mg/mL (60.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years