DMH-25 是一种新型共价有效的 mTOR 抑制剂，在体内对三阴性乳腺癌细胞具有抗肿瘤活性。

DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.

In vivo, DHM25 was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology. Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers.

1685280-21-0

C15H8Br3NO3

489.945

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years