NV-5138 是一种具有选择性的、口服活性的脑内mTORC1激动剂，能够与 Sestrin2 结合。它是一种亮氨酸类似物。它可用于抗抑郁的生物研究。

NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.

NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].?NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2].

2095886-80-7

C7H13F2NO2

181.18

DMSO:1.81 mg/ml (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years