Chk1-IN-3 是一种检测点激酶 (Chk1) 抑制剂，IC50 值为 0.4 nM。

CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).

CHK1-IN-3 displays a low affinity for hERG (IC50 >40 μM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 μM)[1].

In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1].

2097252-39-4

C20H23N9O

405.46

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years