KSI-3716 is an inhibitor of c-Myc.

KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0.84 μM).?c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM.?The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased.?KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters.

Perfusion of KSI-3716 through the bladder at a dose of 5 mg/kg can significantly inhibit tumor growth with minimal systemic toxicity.

1151813-61-4

C17H11BrCl2N2O2

426.09

DMSO:5 mg/mL (11.73 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years