Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-Κb，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-Κb而诱导肿瘤细胞凋亡。

Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L).

25990-37-8

C27H30O7

466.52

DMSO:60 mg/ml (128.61 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years