AC264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂，pEC50为 7.5。

AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.

1051487-82-1

C19H18BrN3O2

400.276

AC264613

DMSO:40 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years