Sigma-LIGAND-1 是一种选择性 sigma 受体配体，在 DTG 和 PPP 位点的 IC50 分别为 16 nM，19 nM。Sigma-LIGAND-1 对多巴胺 D2 受体的 Ki 为 4000 nM。

Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor.

Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds[1].

139652-01-0

C27H33NO4

435.56

DMSO:90mg/mL (206.6mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years