Mas7 acetate(145854-59-7 free base) 是一种乳酪素的结构类似物，是已知的异源三聚体 Gi 蛋白及其下游效应物的激活剂。

Mas7 acetate, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.

Mas7 produces several biological effects in different cell types. The effect of Mas7 on endogenous mono-ADP-ribosyltransferase activity is in the micromolar range with a maximal activation of 205% over the basal. In pertussis treated plasma membranes, it is found that the effect of Mas7 on endogenous mono-ADP-ribosyltransferase is partially blocked, which suggests the involvement of G-proteins, such as Gi or G0[1]. Mas7 is a basic tetradecapeptide isolated from isp venom, which activates guanine nucleotide-binding regulatory proteins (G-proteins) and stimulates apoptosis. In smooth muscle cells, Mas7 leads to an increase in the perfusion pressure. Vascular contraction is induced by Mas7. The vasoconstriction triggered by mas-7 exhibited a slower increase compared to that simulated by phenylephrine or vasopressin[2]. Exposure of hippocampal neurons to a low dose of Mas-7 increases dendritic spine density and spine head width in a time-dependent manner. Additionally, Mas-7 enhances postsynaptic density protein-95 (PSD-95) clustering in neurites and activates Gαo signaling, increasing the intracellular Ca2+ concentration[3].

TP1107L

C69H128N18O17

1481.86

Mastoparan 7 acetate

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years