GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.

93438-65-4

C88H138N26O44

2264.21

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years