ACY-1083 是一种选择性和脑穿透性 HDAC6 抑制剂 (IC50：3 nM)，可有效逆转化疗引起的周围神经病变。

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.

ACY-1083 (30 and 300 nM) dose-dependently improves cell viability[2].

In C57BL/6J mice, ACY-1083 (10 mg/kg; i.p.) effectively relieves Cisplatin-induced mechanical allodynia. In adult male SD rats, ACY-1083 (3 mg/kg; orally) reverses Paclitaxel-induced mechanical allodynia. ACY-1083(5 mg/kg; i.p.) shows a Cmax of 936 ng/mL, a half-life (T1/2) of 3.5h, and a biologically active plasma exposure of 8 hours[1].

1708113-43-2

C17H18F2N4O2

348.35

DMSO:180mg/mL (516.7mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years