WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

在小鼠β细胞系R7T1中,WS3诱导细胞增殖（EC50=0.074 μM）。在原代胚胎和成人视网膜色素上皮细胞中,WS3可逆诱导细胞发生增殖。

R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

1421227-52-2

C28H30F3N7O3

569.589

H2O:<1 mgml
DMSO:93 mg/mL (163.3 mM)
Ethanol:74 mg/mL (129.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years