PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂，IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。

PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.

In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner[1].

In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively[1].

1401089-31-3

C21H22N2O6S

430.47

DMSO:95 mg/mL (220.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years