MAZ51 是一种VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活，而没有阻断 VEGF-C 介导的VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡，具有抗肿瘤活性。

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.

MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines[1].

In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions[1].

163655-37-6

C21H18N2O

314.388

DMSO:3.33 mg/ml(10.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years