RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

Dose-dependent lymphopenia of CD4+ T cells elicited by RP-001 hydrochloride. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels.

Dose-dependent rapid lymphopenia caused by RP-001 hydrochloride(EC50 of 0.03 mg/kg).

1781880-34-9

C24H25ClN4O4

468.93

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years