Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), generated from the 15-H2t-isoprostane endoperoxide.

65085-69-0

C20H32O5

352.471

ent-Prostaglandin E2

DMF:50 mg/mL
Ethanol:50 mg/mL
PBS (pH 7.2):2 mg/mL
DMSO:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years