FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all).

162341-24-4

C13H16O4

236.26

Dichloromethane:Soluble
Ethanol:Soluble
Methanol:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years