(S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50<1 nM. (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

T13671L

C23H34Cl2N4O3S

517.51

(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base);E3 ligase Ligand 1 dihydrochloride;VHL ligand 2 dihydrochloride

DMSO:100 mg/mL (193.23 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years