LenalIDOmide-Br 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 LenalIDOmide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC STAT3 降解剂 SD-36。

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36.

Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs which are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

Lenalidomide-Br 可以通过接头与蛋白质的配体连接以形成 PROTAC。PROTAC 是泛素介导的促癌蛋白降解的诱导剂[1][2]。

2093387-36-9

C13H11BrN2O3

323.14

DMSO:30 mg/mL (92.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years