CCT367766 is the PROTAC-based pirin targeting protein degradation probe, depletes pirin protein expression at low concentration. It shows a moderate affinity for the CRBN-DDB1 complex (IC50: 490 nM). CCT367766 reveals a good affinity for the recombinant pirin and CRBN (Kds: 55 nM and 120 nM).

CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells. CCT367766 (50-1500 nM; 24 hours) demonstrates the depletion of pirin protein as a?time-dependent hook-effect in SK-OV-3 human ovarian cancer cells.

2229856-58-8

C49H48ClN7O11

946.4

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years