Millepachine 是分离自中草药Millettia pachycarpaBenth 的查尔酮，在体内外对多种人类癌细胞均显示出强大的抗增殖作用。

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM[1].

Millepachine (20 mg/kg; i.v.) reduced tumor volume and tumor weight with the inhibitory rate of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively. Millepachine does not induce acquired drug resistance in an excised A2780S xenograft model[1].

1393922-01-4

C22H22O4

350.414

DMSO:100 mg/mL (285.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years