Kavain是从卡瓦胡椒中分离出来的卡瓦酸内酯，可以正向调控GABAA受体，具有抗焦虑作用。

Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.

Kavain treatment in RAW264.7 cells deactivated MyD88 and Akt, inhibited LITAF, and reduced the production of TNF-α, IL-27, and MIG in response to LPS. Similarly, it had a significant in vivo anti-inflammatory effect on wild-type (WT) mice that developed Collagen Antibody Induced Arthritis (CAIA).

3155-48-4

C14H14O3

230.263

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years