EACC 是自噬的可逆抑制剂，可阻断自噬通量。它对自噬体特异性的 SNARE Stx17 易位具有选择性抑制作用，从而阻止自噬体与溶酶体的融合。

EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. EACC is a reversible autophagy inhibitor.

EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17.EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function.

864941-31-1

C13H11N3O6S2

369.37

DMSO:16.88 mg/mL (45.70 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years