GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). GSK319347A inhibits IKK2 (IC50: 790 nM).

IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. GSK319347A (Compound 1) inhibits TBK1 enzyme (IC50: 93 nM), which also translates into good cell potency (72 nM). IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor (IC50 of 790 nM)[2].

862812-98-4

C22H19N3O5S2

469.53

DMSO:45 mg/mL (95.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years