OSBPL7-IN-1 是口服有效的氧甾醇结合蛋白样 7 (OSBPL7)抑制剂。它促进质膜上ABCA1的增加，但不影响 mRNA 表达。

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].

OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1].

1269826-44-9

C20H19Cl2F3N2O3

463.28

DMSO:250 mg/mL (539.63 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years