Ro60-0175 是一种有效的选择性 5-HT2C 受体激动剂。 Ro60-0175 减少可卡因自我给药和在寻求药物行为消失后恢复反应。

Ro60-0175 is an effective and selective 5-HT2C receptor agonist. Ro60-0175 reduces cocaine self-administration and cocaine recovery after drug-seeking behavior disappeared.

Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) significantly reduces responding on the active lever in the reinstatement group. Ro60-0175 (1 mg/kg; s.c.) preserves the regularity of responding seen in control animals in the drug-treated group, but drug-treated animals reach their break-points earlier. Ro60-0175 (1 mg/kg; s.c.) reduces responding for cocaine and effect is reversed by SB242084 (0.5 mg/kg; i.p.). Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) with the combination of yohimbine (1 mg/kg; i.p.) dose-dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].

169675-08-5

C11H12ClFN2

226.68

Ro60-0175

DMSO:120 mg/mL (529.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years