L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂，其在大鼠和人体中的Ki分别为 5.4 nM 和 2.0 nM。

L-765314 is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B. It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure.

L-765314 shows weak potency for inhibiting the pressor response to either phenylephrine or A-61603 (AD25>3 mg/kg for each).?On the basis of the inhibition of pressor responses to the R1a subtype selective agonist A-61603, L-765314 appears to be selective versus the R1a receptor up to a dose of 0.3 mg/kg.?The results of hypotensive potency in rats show that both L-765314 and terazosin tend to decrease heart rate (about 25 bpm at 1 mg/kg iv)[1]

189349-50-6

C27H34N6O5

522.606

DMSO:50 mg/mL (95.68 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years