Stachydrine 是中国草本植物益母草的主要成分，具有促进血液循环和消除血瘀的功效。Stachydrine能够抑制NF-κB信号通路。

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.

Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05).

Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot.

471-87-4

C7H13NO2

143.186

N,N-Dimethyl-L-proline;Methyl hygrate betaine;水苏碱;Proline betaine;L-stachydrine

H2O:32 mg/mL (223.49 mM)
DMSO:26 mg/mL (181.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years