hydrocotarnine 是 Cbl 的抑制剂。

hydrocotarnine is an inhibitor of Cbl.

In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment[2].

550-10-7

C12H15NO3

221.25

DMSO:55 mg/ml (248.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years