Quercetin dihydrate 是一种黄酮类天然产物，可激活或抑制许多蛋白质的活性。它可激活SIRT1，也可抑制PI3K，抑制 PI3K γ、PI3K δ和PI3K β 的IC50值分别为 2.4 μM、3.0 μM和 5.4 μM。

Quercetin is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects.

Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1]

LD50: Mice 159 mg/kg (i.g.) [2]

6151-25-3

C15H10O7·2H2O

338.27

Sophoretin;槲皮素

DMSO:62 mg/mL (183.3 mM)
Ethanol:15 mg/mL(44.3 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years