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(E)-Guggulsterone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E)-Guggulsterone图片
CAS NO:39025-24-6
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议

产品介绍

产品描述

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4

Cas No.

39025-24-6

分子式

C21H28O2

分子量

312.45

储存和溶解度

DMSO:0.25 mg/mL
DMF:10 mg/mL
DMF:PBS (pH 7.2) (1:4):0.2 mg/mL
Ethanol:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years