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INH6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
INH6图片
CAS NO:1001753-24-7
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)322.42
FormulaC19H18N2OS
CAS No.1001753-24-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 64 mg/mL (198.5 mM)
Water: <1 mg/mL
Ethanol: 11 mg/mL (34.1 mM)
Other info

Chemical Name: N-[4-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-yl]benzamide

InChi Key: WCZLNJTXHZPHLM-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)

SMILES Code: O=C(NC1=NC(C2=C(C)C=C(C)C=C2C)=CS1)C3=CC=CC=C3

Synonyms

INH6; INH-6; INH 6

实验参考方法
In Vitro

In vitro activity: INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis.


Cell Assay: Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.

In Vivo
Animal model
Formulation & Dosage
References

J Med Chem. 2009 Mar 26;52(6):1757-67.