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Riboflavin Tetrabutyrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Riboflavin Tetrabutyrate图片
CAS NO:752-56-7
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Riboflavin Tetrabutyrate 是一种亲脂性黄素衍生物,具有抗氧化和脂质过氧化物去除活性。

产品描述

Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.

体外活性

Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. During the process of the enzymic oxidation-reduction reaction, Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids[1].

体内活性

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver, and so on through the inhibition of lipid peroxide, thereby resulting in a decrease of the elevated serum lipid. The increase in hepatic 3-ketoacyl-CoA thiolase activity indicates that prolonged Riboflavin Tetrabutyrate administration induces an increased beta-oxidation of fatty acid in the liver. Feeding of Riboflavin Tetrabutyrate causes an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected [1][2].

Cas No.

752-56-7

分子式

C33H44N4O10

分子量

656.72

储存和溶解度

DMSO:100 mg/mL (152.27 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years