Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).

Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2. Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively.

254886-77-6

C25H28O7

440.49

苦参醇X

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years