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Albendazole(SKF-62979)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Albendazole(SKF-62979)图片
CAS NO:54965-21-8
规格:≥98%
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)265.33
FormulaC12H15N3O2S
CAS No.54965-21-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 17 mg/mL (64.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate

InChi Key: HXHWSAZORRCQMX-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

SMILES Code: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC

SynonymsSKF-62979; Albendazole; SKF62979; Zentel; SKF 62979; Albenza; Eskazole; Valbazen
实验参考方法
In Vitro

In vitro activity: Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle.

In VivoAlbendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs.
Animal modelRats
Formulation & Dosagei.v. and i.r. administrations.
References

Toxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45.