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Ansatrienin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ansatrienin B图片
CAS NO:82189-04-6
包装:5 mg
市场价:7000元

产品介绍

产品描述

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

Cas No.

82189-04-6

分子式

C36H50N2O8

分子量

638.79

储存和溶解度

Ethanol:Soluble
DMSO:Soluble
Methanol:Soluble
DMF:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years