UNC 0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂,IC50分别为 6 和 15 nM,对G9a/GLP的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平,IC50为 26 nM。
产品描述
UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
Cas No.
1320288-17-2
分子式
C36H59N7O2
分子量
621.9
别名
UNC 0646
储存和溶解度
DMSO:30 mg/mL (48.24 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years