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MI-2(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MI-2(hydrochloride)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议

产品介绍

产品描述

MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).

体外活性

In HEK293 cells, MI-2 accessed the protein target menin-MLL and effectively inhibited the menin-MLL-AF9 interaction. MI-2 effectively blocked cell proliferation, and induced cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations MLL-AF9 and MLL-ENL, with the GI50 value of about 5 μM for MI-2. MI-2 showed little effect on the cell growth of E2A-HLF transduced BMC with the GI50 of >50 μM. MI-2 specifically reduced the immortalization potential of cells transformed with MLL fusion oncoproteins by downregulating the expression of target genes required for MLL fusion protein oncogenic activity [1].

体内活性

After 7 days of treatment with MI-2, MLL-AF9 transformed BMC showed great morphology changes and the expression of CD11b was greatly increased [1].

Cas No.

T22978

分子式

C18H25N5S2·2HCl

分子量

448.5

储存和溶解度

Ethanol:≤30mg/mL
DMSO:10mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years