MI-773 是一种有效的Mdm2-p53蛋白质相互作用 (PPI) 抑制剂，对 Mdm2 具体高结合亲和力 (Kd=8.2 nM)。MI-773 具有抗肿瘤活性。

MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (K d =8.2 nM). MI-773 has antitumor activity [1] [2].

SAR405838 (MI-77301), an analog of MI-773, displays 10 times higher binding affinity against MDM2 than MI-773 (K d =62 vs 8.2 nM). The antitumor activity of MI-77301 is more pronounced in a set of wild type p53 xenograft models than MI-773, including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor, LNCAP human prostate tumor and human acute lymphoblastic leukemia [1].

1303607-07-9

C29H34Cl2FN3O3

562.5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years