PCNA-I1 是PCNA(增殖细胞核抗原)抑制剂。它能够直接与 PCNA 三聚体结合(Kd:0.41 μM)，在体内外均表现出抗肿瘤活性。

PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.

PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1]

Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1].

444930-42-1

C17H14N2O2S

310.37

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