LIN28 inhibitor LI71 是一种有效的细胞渗透性 LIN28 抑制剂，可消除 LIN28 介导的寡尿苷酸化，IC50 为 7 uM。它能直接绑定 CSD，抑制 LIN28 对 let-7 的作用活性。

LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.

LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells.

1357248-83-9

C21H21NO3

335.4

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years