Slingshot inhibitor D3 是具有选择性、竞争性、可逆性的Slingshot抑制剂。它对Slingshot 1和Slingshot 2具有相似的抑制活性。它对Slingshot 1 的IC50为 3 μM；对Slingshot 2 的Ki为 3.9 μM。

Slingshot inhibitor D3 is a potent inhibitor of the Protein Phosphatase Slingshot.

Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2.

Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot.

1715076-35-9

C25H19NO4S2

461.55

JHN76359

DMSO:23.08 mg/mL (50 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years