Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.[2]

1632125-79-1

C21H22FN3O5S2

479.55

DMSO:1 mg/mL
DMF:5 mg/mL
DMF:PBS(pH 7.2)(1:1):0.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years