Anticancer agent 73 (compound CIB-3b) 是一种抗癌剂，可有效靶向反式激活反应(TAR) RNA 结合蛋白 2 (TRBP)并破坏TRBP-Dicer 相互作用。Anticancer agent 73 通过调节 HCC 细胞中 miRNA 组和蛋白质组的表达谱，在体外和体内抑制肝癌细胞(HCC)的生长和转移。

Anticancer agent 73 (compound CIB-3b) is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells[1].

Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the E-cadherin expression and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells. Anticancer agent 73 inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting biogenesis of miRNA [1].

Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) reduces the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice [1]

124811-87-6

C14H15NO4

261.27

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years