Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited virus growth with an average 50% inhibitory concentration (IC50: 1.8 microM) corresponding IC50s were 0.10 microM for FLT (3'-deoxy-3'-fluorothymidine) and 0.23, 0.49, and 0.03 microM for the approved agents AZT, ddI (2',3'-dideoxyinosine), and ddC (2',3'-dideoxycytosine), respectively.

119644-22-3

C9H10ClFN2O4

264.64

DRG-0215;BW-935U-83;935U-83;FCU;FddClUrd

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years