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Sofalcone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sofalcone图片
CAS NO:64506-49-6
包装与价格:
包装价格(元)
100 mg电议
500 mg电议
1 g电议

产品名称
SU-88
索法酮
产品介绍
Sofalcone 可诱导血红素加氧酶-1在胃肠上皮中的表达,是一种抗胃溃疡剂。

产品描述

Sofalcone, a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

体外活性

Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression than the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis shows that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs.

细胞实验

Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification.

Cas No.

64506-49-6

分子式

C27H30O6

分子量

450.531

别名

SU-88;索法酮

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years