Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kinase II inhibitor (IC50: 0.74 μM).

Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation. Hematein (50 and 100 μM; 48 hours) causes apoptosis in A427 lung cancer cells. Hematein (10-100 μM; 14 days) inhibits cell growth in A427 lung cancer cells [1].

In A427 lung cancer cell xenografts, Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth[1].

475-25-2

C16H12O6

300.26

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years