AOH1160 是增殖细胞核抗原 (PCNA) 的抑制剂。 AOH1160 通过干扰 DNA 复制导致细胞周期停滞并诱导细胞凋亡。

AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.

AOH1160 selectively kills many types of cancer cells with mean GI50 of 330 nM and does not cause toxicity to nonmalignant cells[1].

2089314-57-6

C25H20N2O3

396.44

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years