Methylproamine是一种与DNA结合的辐射保护剂，可以修复辐射诱导的短暂活性氧。

Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.

Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel[2].

188247-01-0

C28H31N7

465.59

DMSO:41 mg/mL (88.06 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years